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Device On Fire PBIO Doubles
Iovance Issues Cancer Trial Updates Ahead Of ASCO
Meeting, Sending Stock Skyward
Shares
of small-cap biotech Iovance
Biotherapeutics Inc were
making a strong upward move recently
on more than 10 times their
average volume.
Iovance announced multiple updates in conjunction
with online abstracts made available ahead of presentations
at the 2019 American Society of Clinical Oncology, or ASCO,
annual meeting May 31-June 4, in Chicago.
Cervical Cancer Candidate Outshines Keytruda
Iovance released
new interim data from clinical studies of its
tumor-infiltrating lymphocyte, or TIL, therapy LN-145 in
patients with advanced cervical cancer. The company reported
an objective response rate, or ORR, of 44 percent, and a
disease control rate of 89 percent. Merck
& Co., Inc. '
Keytruda, which was used as a reference, showed a 14-percent
ORR.
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TIL is a type of adoptive cell therapy in which the
tumor-fighting T-cells are extracted from the patient's
body, multiplied outside and reintroduced into the body to
fight the tumor.
The mean patient age was 47 and study participants had
undergone a mean of 2.6 prior lines of therapy.
"The interim data from LN-145 present compelling evidence
that TIL therapy, provided as a single administration, could
improve upon current treatments," Amir Jazaeri, a study
investigator, said in a statement.
Melanoma Therapy Holds Up In Heavily Pretreated Population
Updated results from Cohort 2 in the ongoing innovaTIL-01
study of lifileucel in advanced melanoma showed an ORR of 38
percent and a disease control rate of 76 percent in 55
consecutively dosed post-PD-1 patients, Iovance said.
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The patients were heavily pretreated, with a mean of 3.1
lines of prior therapy, including anti-PD-1, and had a high
baseline tumor burden.
At 7.4-month median follow-up, responses were maintained in
the majority of patients, the company said.
First Patient Dosed In Midstage Melanoma Trial
Iovance also said the first melanoma patient in the Phase 2
IOV-COM-202 study has been dosed — the first instance of a
patient naïve to checkpoint inhibitor treatment receiving
the company's TIL therapy in combination with Keytruda.
The
company also said it has entered into a collaboration with Genocea
Biosciences Inc
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